Introduction: Issues that begin with feet can cause persistent pain in the knees, hips, and back. Misalignments of the foot bones and different constructions in the foot can adjust how a person can walk and how the lower limb bears weight as a person moves. To evaluate the influence of total knee arthroplasty on foot pressure changes in varus osteoarthritic knee using pedobarography. Methods: It is a prospective study done at Velammal Hospital, Velammal Medical College and Research Institute, Madurai, Tamil Nadu, India, among patients with primary osteoarthritis with varus deformity undergoing total knee replacement (TKR) from April 2021 to 2023. The inclusion criteria are patients with primary osteoarthritis with varus deformity undergoing TKR. Only patients with grade II varus (10–20°) deformities are included. Patients who satisfied the inclusion criteria and were willing to participate in the study filled out the informed consent form, and preoperative (pre-op) and postoperative (post-op) pedobarography was done and analyzed. Results: Preoperatively, the high-pressure changes were seen in the lateral metatarsal, lateral midfoot, and lateral heel. Postoperatively, there was a significant shift in pressure changes toward medial foot zones, including the hallux, medial metatarsal, central metatarsals, and medial heel. Conclusion: Posttotal knee replacement, the distribution of foot pressure changes toward the normal foot pressure distribution.