Journal of Orthopedics and Joint Surgery

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VOLUME 6 , ISSUE 1 ( January-June, 2024 ) > List of Articles


Comparing the Effectiveness of Intra-articular Injection with Autologous Platelet-rich Plasma vs Hyaluronic Acid vs Platelet-derived Growth Factors in Early Osteoarthritis of Knee Joint

Vidya S Konana, Harish S Yallapura, Sriharsha Bettaswamy, Srinivas P Sivaram, Darshan G Thimmegowda

Keywords : Hyaluronic acid, Intra-articular injections, Knee, Osteoarthritis, Platelet-rich plasma-derived growth factor, Platelet-rich plasma

Citation Information : Konana VS, Yallapura HS, Bettaswamy S, Sivaram SP, Thimmegowda DG. Comparing the Effectiveness of Intra-articular Injection with Autologous Platelet-rich Plasma vs Hyaluronic Acid vs Platelet-derived Growth Factors in Early Osteoarthritis of Knee Joint. 2024; 6 (1):27-34.

DOI: 10.5005/jojs-10079-1134

License: CC BY-NC 4.0

Published Online: 12-01-2024

Copyright Statement:  Copyright © 2024; The Author(s).


Aims: To compare the effectiveness between intra-articular injection (IAI) of autologous platelet-rich plasma (PRP) vs hyaluronic acid (HA) vs activated PRP in primary osteoarthritis (OA) of the knee grades 1 and 2, in terms of pre- and postinjection functional outcome by the Western Ontario and McMaster Universities Arthritis Index (WOMAC) scale, and pre- and postinjection pain by visual analog scale (VAS). Materials and methods: The patients were divided into three groups based on the treatment they received. Group I received an HA injection of 25 mg, group II received an autologous PRP injection, and group III received an activated autologous PRP injection. The patients were evaluated primarily with WOMAC scale improvement and secondarily by VAS at the time of getting the injection (0), at the end of 1 month, and at the end of 3 months. Results: A total of 71 candidates were finally included in the study. Patients’ mean age of HA, PRP, and activated PRP was 54.5 ± 6.79, 55.47 ± 6.31, and 55.73 ± 7.33, respectively. In the HA group, the total WOMAC index decreased from 42.95 ± 3.49 to 21.29 ± 21.29, from 41.52 ± 4.17 to 18.91 ± 1.4 in the PRP group, and from 43.82 ± 4.67 to 18.91 ± 2.44 in the activated PRP group after 3 months (p-value is significant). Regarding the VAS scale, it significantly decreased after 3 months in the activated PRP group compared to others. Conclusion: The data revealed significant improvements in the WOMAC scale and VAS in all the groups at the 1- and 3-month follow-up visits. When comparing the change of WOMAC Scale and VAS at 1- and 3-month follow-ups, significant differences were found between the PRP and HA group and the activated PRP group, with activated PRP showing better outcomes compared to others.

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