Journal of Orthopedics and Joint Surgery

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VOLUME 4 , ISSUE 2 ( July-December, 2022 ) > List of Articles

Original Article

Efficacy of Single Intra-articular Injection of Hyaluronic Acid for Osteoarthritis of the Knee Joint in South Indian Population

Vetrivel Chezian Sengodan, Jenny J Pynadath

Keywords : Hyaluronic acid, Inflammation, Joint pain, Mobility, Osteoarthritis

Citation Information : Sengodan VC, Pynadath JJ. Efficacy of Single Intra-articular Injection of Hyaluronic Acid for Osteoarthritis of the Knee Joint in South Indian Population. 2022; 4 (2):61-65.

DOI: 10.5005/jp-journals-10079-1094

License: CC BY-NC 4.0

Published Online: 31-05-2022

Copyright Statement:  Copyright © 2022; The Author(s).


Background: Intra-articular viscosupplements are one of the effective and safe approaches for clinical management of osteoarthritis (OA). Hyaluronic acid is one such viscosupplement which results in pain relief, reduces use of NSAIDS and delays joint-replacement surgeries. Methods: This study evaluated the efficacy of Hylan GF 20 which is approved for use in India since 2010, in a south Indian population under public health care system. Patients above 40 years of age with osteoarthritis of grade 2, 3, 4 based on KL classification were included. WOMAC score (Western Ontario and McMaster Osteoarthritis Index) was used to evaluate pain, stiffness and functioning of the knee joint. Results: Single intra articular administration of hyaluronic acid progressively decreased the WOMAC score as early as 2 weeks, with the score continued to decline until 6 months of follow up. Compared to the baseline, a 43 percent improvement in WOMAC score was observed at 6 months, reflecting a significant clinical efficacy of Hylan GF 20. Most drastic reduction in the WOMAC score observed in the grade 2 OA subgroup followed by grade 3 and 4 OA subgroups. Conclusion: The results of this study supports the use of Hylan GF 20 for the treatment osteoarthritis of knee as a single injection which can be easily adopted to public health service measures as a day care procedure.

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