This article displays the current ideology in the therapy of antibiotics. It also explains the various guidelines for safe usage with a precise choice of antibiotics in orthopedic and trauma surgery including prophylaxis in the prevention of surgical site infection.
WHO Model List of Essential Medicines for 2017, Press Release of World Health Organisation, Geneva on 6 June 2017.
Oishi CS, Carrion WV, Hoaglund FT. Use of parenteral prophylactic antibiotics in clean orthopaedic surgery: a review of literature. Clin Orthop Relat Res 1993;296:249–255.
Standards for the management of open fractures of the lower limb (2009), The British Association of Plastic, Reconstructive and Aesthetic Surgeons.
Campbell KA, Stein S, Looze C, et al. Antibiotic stewardship in orthopaedic surgery: principles and practice. J Am Acad Orthop Surg 2014;22(12):772–781. DOI: 10.5435/JAAOS-22-12-772.
Rajkumari N, Gupta AK, Mathur P, et al. Outcomes of surgical site infections in orthopaedic trauma surgeries in a tertiary care centre. J Postgrad Med 2014;60(2):254–259. DOI: 10.4103/0022-3859.138731.
Varley AJ, Sule J, Absalom AR. Principles of antibiotic therapy, continuing education in anaesthesia. Critical Care Pain 2009;9(6):184–188. DOI: 10.1093/bjaceaccp/mkp035.
Dryden M. Surgical antibiotic prophylaxis. Surgery 2018;37(1):19–25.
Farooqui HH, Mehta A, Selvaraj S. Outpatient antibiotic prescription rate and pattern in the private sector in India: evidence from medical audit data. PLoS One 2019;14(11):e0224848. DOI: 10.1371/journal.pone.0224848.
National Treatment Guidelines for Antimicrobial Use in Infectious Diseases, National Centre for Disease Control, Directorate General of Health Services, Ministry of Health & Family welfare, Government of India, 2016.
Treatment Guidelines for Antimicrobial use in common syndromes, Indian Council of Medical Research, Department of Health Research, New Delhi, India 2017.
Amaradeep G, Shivaprakash SS, Manjappa CN. Surgical site infections in orthopaedic implant surgery and its risk factors: a prospective study in teaching hospital. Int J Orthop Sci 2017;3(3):169–172.
Road Accidents Analysis in Tamil Nadu, January 2019, Home (Transport) Department, Government of Tamil Nadu.
Leekha S, Terrell CL, Edson RS. General principles of antibiotic therapy. Mayo Clin Proc, 2011;86(2):156–167. DOI: 10.4065/mcp.2010. 0639.
Salkind AR, Rao KC. Antibiotic prophylaxis to prevent surgical site infections. Am Family Physic 2011;83(5):585–590.
Chahoud J, Kanafani Z, Kanj SS. Surgical site infections following spine surgery: eliminationg the controversies in the diagnosis. Front Med 2014;1(7):1–9. DOI: 10.3389/fmed.2014.00007.
Ceroni D, Grumetz C, Desvachez O, et al. From prevention of pin-tract infection to treatment of osteomyelitis during paediatric external fixation. J Child Orthop 2016;10(6):605–612. DOI: 10.1007/s11832-016-0787-8.
Damian Dhar A. Cellulitis – Symptoms, Causes & Treatment, MSD Manual Consumer Version, October 2019.
Soriano A, Garcia-Ramiro S, Mensa J. Infection and local treatment in orthopaedic surgery. ch. 5. Springer; 2019. pp. 49–57.
Surgical site infections: prevention and treatment (2019), NICE Guidelines, UK.
Antimicrobial stewardship: systems and processes for effective antimicrobial medicine use (2015), NICE Guidelines, UK.
Antimicrobial stewardship programmes in health care facilities in Low and middle income countries, A World Health Organisation (WHO) Tool Kit, 2019.